Awọn Aṣiri Iyipada Ajẹsara ti Coriolus Versicolor
Corilus versicolor lulú jẹ yo lati awọn ara eleso ti olu oogun to ṣọwọn yii. Iwadi ode oni fihan pe o ni alailẹgbẹ ninuAwọn peptides polysaccharides (PSP)atipolysaccharides (PSK)awọn eka. Bawo ni awọn eroja ti nṣiṣe lọwọ wọnyi ṣe n ṣiṣẹ nipasẹ ọpọlọpọ{1} awọn ilana ibi-afẹde lati ṣiṣẹ gẹgẹbi “olutọju akàn” ati “oludabobo ẹdọ”?
Awọn paati Nṣiṣẹ Mojuto ati Awọn ilana
Polysaccharides Peptide (PSP)
Imuṣiṣẹsẹhin Sentinel ajesaraṢe alekun idagbasoke sẹẹli dendritic nipasẹ 3 × ati ṣiṣe igbejade antigen nipasẹ 50%
Anticancer Synergy: Ṣe ilọsiwaju awọn ipa inhibitor PD-1 (ilosoke 35% ni oṣuwọn isunki tumo)
Idaabobo Radiation: Din post - apoptosis lymphocyte radiotherapy (oṣuwọn idabobo 60%)
Polysaccharides (PSK)
Idinamọ tumo tumo: Ti dinku ifasilẹ sẹẹli tumo MMP-2/9 (idinku 70% ni agbara metastatic)
Hepatocyte isọdọtun: Ṣe jijẹ ifasilẹ ifosiwewe idagbasoke ẹdọ (40% isunmọ yiyara)
Antiviral olugbeja: Ṣe idinamọ asopọ ọlọjẹ HIV si awọn olugba CD4 (IC{1}}ug/mL)
Triterpenoids
Chemo-Ipakupa: Din cisplatin kuro - ibajẹ kidirin ti o fa (dinku 45% ni omi ara creatinine)
Iṣapeye Bile: Ṣe alekun awọn paati bile acid anfani (2× akoonu UDCA ti o ga julọ)
Mitochondrial Idaabobo: Ntọju 80% awọn ipele ATP hepatocyte labẹ hypoxia
Awọn Anfani Ifọwọsi Ile-iwosan
Akàn Adjunctive Therapy
Faagun iwalaaye agbedemeji ni alakan inu nipasẹ awọn oṣu 8.5 (idanwo Ipele III)
55% idinku ninu itankalẹ - mucositis ẹnu ti o fa
Iṣakoso Arun Ẹdọ
Idinku 2-3log ni ẹru gbogun ti HBV DNA (ẹkọ-ọsẹ 48)
Ilọsiwaju 35% ninu awọn ikun fibrosis ẹdọ ọra ọti-lile
Atunse ajesara
60% yiyara CD{1}} ifiweranṣẹ imularada ifiweranṣẹ{2}}kimoterapi
40% kekere ikolu oṣuwọn lẹhin ọra inu egungun
Iredodo Onibaje
Oṣuwọn idariji 68% ni ulcerative colitis
25% idinku ninu rheumatoid ifosiwewe
Ilana Lilo Itọkasi
|
Ohun elo |
Fọọmu to dara julọ |
Asami iṣẹ |
Iwọn ojoojumọ |
Ayika Itọju |
|
Akàn Adjunct |
PSP jade |
Awọn sẹẹli CD 83+ DC |
1-2g |
Ni igbakanna pẹlu chemo/radiation |
|
Ẹdọ Support |
Ni kikun {{0}Spectrum Powder |
ALT/AST |
3-5g |
3-6 osu |
|
Iyipada Ajẹsara |
PSK awọn capsules |
NK Cell aṣayan iṣẹ-ṣiṣe |
500mg |
Lilo Lainidi |
Scientific Apapo ogbon
Pẹlu SeleniumṢe alekun iṣẹ ṣiṣe glutathione peroxidase (GPx) nipasẹ 30%
Pẹlu Boswellia Extract: Meji NF-κB/COX{3}}2 idinamọ (2.3× egboogi-iredodo ipa)
Pẹlu Probiotics: Ṣe ilọsiwaju chemo{0}} gbuuru ti o jọmọ (ipa 50% ti o ga julọ)
Pataki Awọn iṣọra
⚠ Ipa Window IwosanTi o kọja 5g fun ọjọ kan le fa ajẹsara (nilo abojuto)
⚠ Awọn ilana Iṣẹ abẹ: Da ọsẹ meji duro ṣaaju -op (ewu ẹjẹ)
⚠ Awọn Arun Aifọwọyi: Nbeere ibojuwo ajẹsara ti o sunmọ
Didara Gold Standards
① Isediwon ara eso (kii ṣe mycelium)
② Meji-imọ ẹrọ ilokulo (iwọntunwọnsi PSP/PSK)
③ Idanwo irin ti o wuwo (Pb<0.5ppm)
Awọn ijẹrisi olumulo
"Awọn ipele AFP iduroṣinṣin lẹhin itọju ailera akàn ẹdọ" - 52M (pẹlu itọju aṣa)
"Ẹnigbo HBV onibajẹ ti ṣaṣeyọri aisi-ara nikẹhin" - 38F (papọ pẹlu awọn egboogi)
Mechanistic Breakthroughs
Iṣatunṣe Iyẹwo Ajẹsara(Awari 2023):
Ṣe alekun tumo -CD ti n wọ inu 8+ T sẹẹẹli (2.3×)
Din iwọn Treg dinku (25%→12%)
Gut- Ilana Ẹdọ:
Ṣe alekun butyrate{0}} ti nmu kokoro jade (Faecalibacterium 3.5×)
O dinku awọn ipele endotoxin (42%)
Kini o jẹ ki Corilus jẹ alailẹgbẹ?
Ti a fiwera si -awọn oogun apakokoro akàn, o funni:
Iṣatunṣe ajẹsara meji ati iṣe antitumor taara
Idaabobo eto ara ni idapo pẹlu imudara itọju ailera
Ifọwọsi ode oni ti ẹkọ ibile “Fu Zheng Qu Xie”.
